TXA Doesn't Work!
......or so they said.
A recent systematic review evaluated how effective Tranexamic Acid (TXA) is for trauma patients in emergency settings:
➡ The Study focused on TXA's effectiveness in emergency trauma cases.
➡ Included 7 randomized controlled trials.
➡ Primary endpoint: 1-month mortality.
📉 Main Results:
➊ 11% decrease in death risk at 1 month after TXA use (OR 0.89, 95% CI 0.84 to 0.95).
➋ Reduced 24-hour mortality with TXA (OR 0.76, 95% CI 0.65 to 0.88).
➌ No significant increase in vascular occlusive events (OR 0.96, 95% CI 0.73 to 1.27).
👀 Subgroup Insights:
➊ TXA more effective in general trauma than traumatic brain injury.
➋ Out-of-hospital TXA administration linked to lower mortality than in-hospital.
➌ No major differences in blunt vs. penetrating trauma.
Conclusions:
➡TXA in emergencies leads to reduced 1-month mortality.
➡No problematic increase in vascular occlusive events.
➡Earlier, out-of-hospital administration might be more beneficial.
Ready to dive deeper into this fascinating topic? 🧐 Check out the full study here: https://ow.ly/H6Wl50QliLg